男性不育患者血清抗精子抗体与精液主要参数的关系分析

Relationship between serum antisperm antibodies and main parameters of semen in male infertility patients

目的探讨血清抗精子抗体(AsAb)对精子主要参数的影响。方法用酶联免疫吸附试验(ELISA)对143例男性不育症患者血清中的AsAb进行检测,根据结果分为AsAb阳性组和阴性组,比较两组患者精子密度、精子活动率、a+b级活动精子率、畸形率等参数。结果143例男性不育症患者血清AsAb阳性30例,占被检人数的20.98%。血清AsAb阳性组精液参数中精子密度、精子活动率、a+b级活动精子率统计结果均低于AsAb阴性组的相应参数统计结果,而血清AsAb阳性组精子畸形率明显高于AsAb阴性组。两组间各项参数比较差异均有统计学意义(P<0.01或P<0.05)。结论血清AsAb对精液主要参数有明显影响,是导致男性免疫性不育的重要因素之一。

Objective To study the effects of the serum antisperm antibodies on the main parameters of semen. Methods The 143 cases of male infertility were selected and divided into the serum antisperm antibody positive group and negative group by the enzyme-linked immunosorbent assay method. A comparison among the semen items which included the sperm density, the sperm activity rate, the sperm a＋b activity and the sperm deformity rate of two groups were made. Results The 30 cases were the serum antisperm antibody positive and the percent was 20. 98% in the 143 cases. The statistical results of the sperm density,the sperm activity rate,the sperm a＋b activity of the serum antisperm antibody positive group were lower than those of the serum antisperm antibody negative group,but the statistical result of the sperm deformity rate of the positive group was obviously higher than that of another group. The difference between them was significant （P〈0.01 or P〈0.05） by comparing these items of the two groups. Conclusion The influence of serum antisperm antibody on the main parameters of semen is distinct and the antisperm antibody is one of the important factors resulting in the male immune infertility.