摘要
为探讨CD28单克隆抗体在移植免疫中的作用,以混合淋巴细胞培养和大鼠同种异体甲状旁腺移植为模型,观察mAbCD28在体外和体内实验中的作用。结果:mAbCD28在体外可以抑制淋巴细胞的增殖,在体内可以延长甲状旁腺移植物的存活时间。本实验结果提示:mAbCD28可以阻断CD28B7之间共刺激信号的传递,并在同种异体大鼠甲状旁腺移植中起到免疫抑制作用。
To verify the role of mAbCD28 in allograft transplantation. The biological action of mAbCD28 had been tested in mixed lymphocyte reaction and parathyroid gland allotranplantation in rats. Results: mAbCD28 could significantly suppress the proliferation of T cells in vitro and prolong the survival time of allograft in vivo. The results showed that mAbCD28 could block the costimulatory signals transmitted by CD28 molecules, and played an immunosuppressive role in parathyroid gland transplantation in rats.
出处
《中国普外基础与临床杂志》
CAS
1998年第5期260-262,共3页
Chinese Journal of Bases and Clinics In General Surgery
关键词
CD28
单克隆抗体
甲状旁腺
移植免疫
同种移植
CD28 Costimulatory pathway Parathyroid gland transplantation Transplant immunology