乳腺癌P62^(C-myc)蛋白表达与雌激素和孕激素受体的关系及其临床意义

RELATIONSHIP OF P62 C myc PROTEIN EXPRESSION TO ESTROGEN PROGESTERONE RECEPTORS IN BREAST CANCER AND ITS CLINICAL SIGNIFICANCE

为探讨乳腺癌Ｐ６２Ｃｍｙｃ蛋白表达与雌激素和孕激素受体的关系及其临床意义，采用ＬＳＡＢ免疫组化法对１０７例乳腺癌标本进行Ｐ６２Ｃｍｙｃ蛋白检测。结果：Ｐ６２Ｃｍｙｃ蛋白表达阳性率为６３．５５％（６８／１０７），在生存时间≤５年、＞５年＜１０年及≥１０年者，其Ｐ６２Ｃｍｙｃ蛋白表达阳性率分别为９４．００％（４７／５０），６５．００％（１３／２０）和２１．６２％（８／３７），表明Ｐ６２Ｃｍｙｃ蛋白过度表达与乳腺癌的临床分期晚、组织学分级高及腋淋巴结转移有关，而与雌、孕激素受体状况关系不大。由此提示：Ｐ６２Ｃｍｙｃ蛋白表达可作为判断乳腺癌预后的一个重要指标。

In order to understand the relationship of P62 C myc protein expression to ER and PR in breast cancer and its clinical significance, we examined expression of P62 C myc protein in 107 breast carcinomas by using immunohistochemical techniques (LSAB). The results showed that the positive rate of P62 C myc protein expression was 63.55% (68/107). The overexpression of P62 C myc protein related negatively with survival. 94.00% of the cases with overexpression of P62 C myc protein survived ≤5 years, 65.00% survived >5 years <10 years and 21.62% survived ≥10 years. There were significant associations of P62 C myc protein expression with advanced clinical stage, high histological grade, and positive axillary node status in breast cancer,but no relationship between hormone receptors and P62 C myc . All of these findings suggest that overexpression of P62 C myc protein might be an important prognostic factor, and the detection of P62 C myc protein might be arranged as a regular pathological examination in the cases of breast cancer.