速避凝对急性脑梗塞自由基和临床转归的影响

Fraxiparine for the treatment of acute cerebral infarcts

目的：探讨速避凝对急性脑梗塞的脑保护作用。方法：设立治疗组与对照组，分别测定各组SOD、MDA值及观临床神经功能缺损改善情况．结果：用药前与用药后3天临床疗效比较，治疗组有显著差异（P＜0．05），与用药后7天、14天、21天比较有极显著差异（P＜0．01），而对照组21天有极显著差异（P＜0．01），余无显著差异（P＞0．05）。用药前后SOD、MDA值比较，治疗组有显著意义（P＜0．05），对照无显著意义（P＞0．05）．结论：速避凝对急性脑梗塞有较显著疗效，这不仅与之抗凝抑制血栓形成作用有关，还可能与与之减少自由基生成，具有保护神经细胞作用有关。

Objective: The effect of Fraxiparine on inhibiting the production of free radical in reperfusion injury after cerebral ischemia and promoting the improvement of clinical symptoms and neurologica signs were studied. METHOD: Patients with acute cerebral infarct were divided into two groups at random: treatment group with Fraxiparine and contol group. we obeserved and recorded the neurological deficit scores and examined the values of SOD and MOA in all of the patients with cerebral infarcts. RESULts:The results revealed that significant differences of neurological deficit scores and the levels of SOD, MDA were found between before and after treatment in group with low molecular weight heparin. CONCLUSION:The date of this paper illustrated that Fraxipaxine has the effect on inhibition of the production of the free radical.