芪众颗粒预防老年人上呼吸道感染的临床研究

Clinical Research of Qizhong Granules for Preventing Upper Respiratory Tract Infection In the Elderly

【目的】观察芪众颗粒对老年人上呼吸道感染的预防作用。【方法】将149例老年病人随机分为芪众颗粒组(A组)50例、玉屏风颗粒组(B组)49例、空白对照组(C组)50例。A、B 2组连续服药7 d,C组不采用任何干预方法。观察时间为2周,主要观察上呼吸道感染发生率以及不同时间点症状体征积分变化,同时采用二项分类Logistic回归法分析与发病的相关性。【结果】(1)A、B、C 3组发生上呼吸道感染例数分别为1例(2.00%)、2例(4.08%)、11例(22.00%),AC、BC 2组间比较差异有显著性意义(P<0.01)。(2)A、B 2组症状体征积分呈下降趋势,在第7天、第14天,A组积分均数均较B组低,B组积分均数均较C组低。A组症状体征积分的改善优于B组,B组症状体征积分的改善优于C组。(3)对上呼吸道感染发病有显著性意义的变量是:畏寒怕冷,自汗。而啰音、腰酸、纳差OR值均大于1,可看作危险因素。芪众颗粒、玉屏风颗粒2种药物均为保护因素,玉屏风颗粒的发病危险是芪众颗粒的4.33倍。【结论】芪众颗粒能有效预防老年病人上呼吸道感染且用药安全。

Objective To evaluate the effect of Qizhong Granules （QG） on preventing upper respiratory tract infection （URTI） in the elderly through clinical observation. Methods One hundred and forty-nine qualified aged patients were randomized into 3 groups： group A （N = 50） received QG, group B （N = 49） received Jade Screen Powder （JSP） , and group C （N = 50） was the blank control group. The treatment lasted 7 continuous days. We observed tile incidence of URTI as well as the changes of symptoms and signs on the 7^th and 14^th day of treatment. Results （1） URTI occurred in 1 （2.00%）,2 （4.08%） andll （22.00%） patients of groups A,B and C, respectively. The differences between groups A and C, and those between groups B and C were significant （P 〈0.01 ）. （2） Analysis of variance of repeated measured data showed an upward trend of symptom scores in groups A, B and C on the 7^th and 14^th day, group A having the lowest symptom score. The improvement of symptom score was the best in group A and better in group B. （3） The results of non-conditional logistic regression showed that aversion to cold and spontaneous sweating were contributed to the onset of URTI. OR value of rale, soreness in the waist, poor appetite was more than 1, which could be regarded as risk factors. Both QG and JSP were protective factors. JSP had 4. 33 times of onset risk as much as QG. Conclusion QG can effectively prevent upper respiratory tract infection in the elderly, and is safe in clinical practice.