中草药犁头草内服外敷对慢性骨髓炎临床疗效的影响

Therapeutic Effect of External Application and Oral Use of Herba Seu Radix Violae Japonicae for the Treatment of Chronic Osteomyelitis

【目的】观察中草药犁头草对慢性骨髓炎临床疗效的影响。【方法】将60例慢性骨髓炎患者随机分为治疗组和对照组各30例。对照组给予西医非手术常规抗生素治疗,治疗组在对照组治疗基础上配合中草药犁头草内服外敷。2组均以7 d为1个疗程,共治疗6个疗程。观察临床疗效并比较两组治疗前及每2个疗程后血沉(ESR)、C反应蛋白(CRP)水平的变化。【结果】治愈率、总有效率治疗组分别为46.67%、86.67%,对照组分别为20.00%、63.33%,两组比较差异均有显著性意义(P<0.05)。治疗组每2个疗程后ESR和CRP水平持续降低(与治疗前比较,P<0.05或P<0.01);与对照组同期比较,治疗组各疗程结束后ESR、CRP的降低作用显著优于对照组(P<0.05或P<0.01)。【结论】中草药犁头草配合抗生素治疗可提高临床慢性骨髓炎的治愈率和有效率,并显著降低患者外周血ESR、CRP水平。

Objective To observe the therapeutic effect of external application and oral use of Herba Seu Radix Violae Japonicae （HSRVJ） for the treatment of chronic osteomyelitis. Methods Sixty chronic osteomyelitis were randomized into the treatment group and the control group. The two groups received conservative routine antibiotic treatment. The treatment group received external application and oral use of HSRVJ additionally. Seven days constituted one treatment course, and the treatment lasted 6 courses. The changes of erythrocyte sedimentation （ESR） and C-reactive protein （CRP） were compared in the two groups before treatment and every 2 courses. Meanwhile, the clinical cure rate and the total effective rate were observed in the two groups. Results The cure rate was 46.67% and the total effective rate was 86.67% in the treatment group, and was 20.00% and 63.33% in the control group respectively. ESR and CRP decreased gradually every 2 courses in the two groups （P 〈 0.05 or P 〈 0.01 compared with those before treatment）, and the decrease in the treatment group was obvious as compared with that in the control group （P 〈 0.05 or P 〈 0. 01 ）. Conclusion HSRVJ combined with antibiotic treatment can increase the cure rate and effective rate, and can decrease peripheral ESR and CRP levels.