不宁腿综合征11例临床分析

Restless legs syndrome:11 cases report

目的探讨不宁腿综合征(RLS)的临床表现及可能的发病机制,观察多巴丝肼对RLS的治疗效果。方法对3年内收治的不宁腿综合征患者11例临床特征和治疗结果进行回顾性分析。结果11例均有活动肢体的迫切愿望,以减轻肢体的不舒服感觉,均在夜间症状加重,其中3例白天也有严重症状。根据国际不宁腿综合征研究组(IRLSSG)的诊断标准,平均得分为24分。经多巴丝肼每晚睡前服用,治疗4周后,多数患者主观症状明显改善,IRLSSG评分明显减少(平均得分14分),其中3例恢复正常。结论多巴丝肼可使RLS临床症状获得明显改善,不良反应较轻,患者依从性好,但长期疗效尚有待于进一步观察。

Objective To investigate the clinical manifestations of restless legs syndrome（RLS） ,and the effects of levodopa/benserazide on the patients with RLS. Methods Clinical manifestations and therapeutic results of 11 cases of restless legs syndrome were retrospectively analyzed. Results Eleven patients all were accompanied with extremities discomfortableness which couldn＇t be able to tolerate, urged to move the extremities, and aggravated at night. The patients were frequently associated with insomnia. The average score was 24 according to the International Restless Legs Syndrome Study Group （IRLSSG）diagnostic criteria. After treatment by levodopa/benserazide 125mg at bedtime each night for 4 weeks, most of patients＇ subjective symptoms improved markedly, and the IRLSSG score was significantly decreased（average score of 14 points）. Conclusion Restless legs syndrome often characterized by the lower extremity diseomfortableness,night aggravated, post exercise relieved, and accompanied with dyssomnia. Restless legs syndrome is mainly diagnosed based on clinical manifestations. Levodopa/ benserazide may be considered as an effective medication for patients with RLS.