不同剂量阿托伐他汀对急性心梗患者血脂、C反应蛋白及IL-6的影响

Effects of different doses of atorvastatin on serum lipid,inflammatory factor Hs-CRP and IL-6 AMI patients

目的观察不同剂量阿托伐他汀对AMI患者血脂、C反应蛋白(CRP)、白介素-6(IL-6)降低幅度的差别,以及hs-CRP和IL-6的关联。方法选取急性心梗患者60例,随机分为2组,一组服用阿托伐他汀10mg/d,另一组服用阿托伐他汀20mg/d,分别在入院12h内、服药后1个月测定患者血脂、hs-CRP,IL-6,比较两组患者血脂、hs-CRP、IL-6的变化。结果两组急性心梗患者治疗1月后血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、hs-CRP、IL-6显著下降(均P<0.01),阿托伐他汀10mg/d组和20mg/d组相比,1月后血脂、hs-CRP、IL-6变化值无统计学差异,hs-CRP和IL-6呈正相关。结论急性心梗患者无论是使用阿托伐他汀10mg/d还是20mg/d治疗1月,都能使血脂水平,包括TC、LDL-C、和炎症指标hs-CRP、IL-6显著下降,但短期内两剂量间并没有显著差异。hs-CRP与IL-6之间存在相关性。

Objeetive AIM：To investigate the effects of different doses of atorvastatin on serum levels of the blood lipid and high-sensitive C-reactive protein （hs-CRP） and IL-6 in patients with AMI and to study the relationship between hs-CRP and IL-6. Methods Sixty consecutive patients with AMI were randomly divided into two groups. Patients in group A were given oral atorvastatin 10 mg once daily and patients in group B were given oral atorvastatin 20 mg once daily. The serum levels of blood lipid and hs-CRP and IL-6 were measured with biochemistry assayl2 hours after admission and 1 month after therapy. The difference in hs-CRP and IL- 6 was compared between the two group s and subset groups. Results The serum levels of total cholesterol, lower density Lipoprotein cholesterol （LDI_2C） ,hs-CRP and IL-6 in the patients of the two groups after taking atorvastatin for a month were significantly lower than those before therapy （ P 〈 0.01 ）. The changes of blood lipid, hs-CRP and IL-6 were not significantly different between the two group s. Conclusion No significanttherapeutic difference has been found in atorvastatin at doses of 10 mg/d or 20 mg/d. After one- month therapy with atorvastatin of 10 mg/d Or 20 mg/d, the seryn levers of blood lip id, including total cholesterol, LDL2C, hs-CRP and are significantly decreased compared with those before therapy in patients of AMI. Hs-CRP is related to IL-6.