孕妇血浆血管性假血友病因子和血清C反应蛋白检测的临床意义

Clinical significance of detection of plasma von willebrand factor and serum C-reactive protein in pregnant women

目的:探讨妊娠期糖尿病并妊娠高血压综合征孕妇血浆血管性假血友病因子(vWF)和血清C反应蛋白(CRP)检测的临床意义。方法:采用酶联免疫吸附法(ELISA)检测20例妊娠期糖尿病并妊娠高血压综合征(GDM并PIH组)、30例妊娠期糖尿病(GDM组)、32例正常孕妇和22例非妊娠妇女血浆vWF和血清CRP的变化。结果:3组空腹血浆vWF和血清CRP浓度明显高于非妊娠对照组,其中GDM组和GDM并PIH组明显高于正常妊娠组,GDM并PIH组明显高于GDM组,差异均有统计学意义(P<0.01)。直线相关分析表明,GDM组、GDM并PIH组孕妇的血浆vWF与血清CRP浓度无显著相关性(r=0.053,P>0.05;r=0.117,P>0.05)。结论:测定GDM并PIH孕妇血浆vWF和血清CRP水平,能够及时发现血管内皮细胞损伤和炎症反应程度,利于预防及早期治疗。

Objective： To explore the clinical significance of detection of plasma von willebrand factor （vWF） and serum C - reactive protein （CRP） in pregnant women with gestational diabetes mellitus （GDM） and hypertensive disorder complicating pregnancy （HDCP） . Methods： The changes of plasma vWF and serum CRP in 20 pregnant women with GDM and HDCP （ GDM ＋ HDCP group）, 30 pregnant women with GDM （GDM group） , 32 normal pregnant women （normal pregnancy group） and 22 non -pregnant women （unpregnancy group） were detected by ELISA. Results： The plasma vWF level and serum CRP level in unpregnancy group were significantly lower than those in the other three groups, the plasma vWF levels and serum CRP levels in GDM group and GDM ＋ HDCP group were significantly higher than that in normal pregnancy group, the plasma vWF level and serum CRP level in GDM ＋ HDCP group were significantly higher than those in GDM group （P 〈 0. 01 ） . There was no correlation between vWF and CRP in GDM group and GDM ＋ HDCP group （γ= 0. 053, P 〉0. 05 ; γ =0. 117, P 〉0. 05） . Conclusion： Detection of plasma vWF and serum CRP in pregnant women with GDM and HDCP may diagnose vascular endothelial cell damage and inflammation reaction degree, which is good for prophylaxis and early treatment.