白癜风角朊细胞内皮素1mRNA表达的研究

Study on the Expression of Endothelin 1 mRNA in Keratinocytes in Patients with Vitiligo

目的 了解白癜风黑素细胞的消失与角朊细胞产生的内皮素 1 (ET 1 )水平的关系。方法采用原位杂交的方法检测了 1 4例进展期寻常型白癜风患者表皮角朊细胞ET 1mRNA表达。结果 白癜风患者白斑区及白斑边缘角朊细胞ET 1mRNA表达明显降低。结论 白癜风的发生可能与角朊细胞所分泌的ET 1等生长因子缺乏有关 ,角朊细胞ET

Objective To study the expression of endothelin 1 (ET 1) mRNA in keratinocytes in patients with vitiligo. Methods Fourteen patients with progressive vitiligo were measured by hybridization in situ. Results Our results showed that the expression of ET 1 mRNA was markedly decreased. Conclusion The results revealed that decreased ET 1 expression may be associated with the pathogenesis of vitiligo. The cause and role of decreasing of ET 1 expression of keratinocyte in vitiligo lesion need to be studied further.