双水杨醛缩乙二胺金属络合物对柠檬烯的催化氧化的条件分析

Analysis of Condition on Oxidation of Limonene Catalyzed by Metal-Salen Complexes

R-(+)-柠檬烯来源广泛且价格相对便宜,以R(+)柠檬烯为原料经局部氧化可获得具有较高附加值的成分,最近的研究显示R-(+)柠檬烯可以被某些双水杨醛缩乙二胺金属络合物催化氧化,这一氧化过程仅仅局限于柠檬烯分子结构的某一部位,氧化剂较为普通,如NaOCl和PhIO等,反应介质通常是常见的有机溶剂,如二氯甲烷、乙酸乙酯、乙腈或丙酮。文章通过研究反应各因素(如催化剂用量、氧化剂类型、溶剂的选择和反应时间等)对目标产物收率的影响,以便获得反应过程的信息。实验中获得的大量数据针对三个主要目标产物(1,2-柠檬烯环氧物、香芹醇和香芹酮)采用了正交分析进行统计分析,显示不同的反应因素对产物选择性的影响存在差异,同时也显示这一数学统计模型能较好地解决反应条件优化问题。

R-（＋）limonene is available and cheap, and the selective oxidation of R（＋）limonene has attracted attention as a promising process for the production of compounds with a higher market value, one of the these processes, described in the recent literature, is submission of R-（＋）limonene to an oxidation reaction catalyzed by neutral or cationic Metal（Salon） complexes, in the presence of effective terminal oxidants such as NaOCI or PhlO. These reactions are commonly carried out in organic solvents （dichromethane, ethyl acetate, acetonitrile or acetone）. The main objective of the present work was to study the effect of several factors （type of oxidant, catalyst, solvent and time） on reaction selectivity. For the purposes, experimental statistical orthogonal analysis was used for experimental design. From the results it was observed that for the three targeted products （1,2-limoneneoxide, carveol or carvone） was different under different condition, and the statistical analysis proved to be suitable for choosing of the best reaction conditions for a specific desired product.