吗替麦考酚酯合成工艺研究

Research on the Synthesis Process of Mycophenolate Mofetil

在文献资料的基础上,文章对吗替麦考酚酯合成工艺条件进行了研究。以吗替麦考酚酸和吗啉醇为原料,考察了反应时间、配料比等对最终产物的影响。最佳合成工艺条件为:反应时间8 h,吗替麦考酚酸和吗啉醇配料摩尔比为1∶1.2。经HPLC检测吗替麦考酚酯成品纯度高于99.5%,平均收率高于80%。

Based on current literature, the paper was aimed to study the synthetic process of Mycopbenolate mofetil. The effects of reaction time, ratio of raw material on the yield of Mycophenolate mofetil were studied. Finally, the optimum technological parameters of the synthetic process were obtained as 8 h, molar ratio of Myeophcnolate acid to morpholine, 1 ： 1.2. The average yield of mycophenolate mofetil was more than 80 % with a purity of 99.5 %.