葛根黄酮EC-PEG载药系统的研究

Studies on isoflavones from radix puerariae drug carrier systems

目的：研究葛根黄酮乙基纤维素（ＥＣ）聚乙二醇（ＰＥＧ）载药系统的释药效果。方法：拟定载药系统组成及制备工艺，用紫外分光光度法对葛根黄酮的含量及溶出度进行测定。结果：乙基纤维素、聚乙二醇及葛根黄酮三者的用量，乙基纤维素、聚乙二醇载药系统粒径大小，制备温度等对葛根黄酮的释放均有影响。载药系统理想的比例为ＥＣＰＥＧ葛根黄酮（５∶０．４∶１）。载药系统可在１ｈ内突释（６０．５１±３．６３）％，后按零级释放，在１０ｈ左右释放完全（９５．０７±３．１２）％。结论：ＥＣ－ＰＥＧ葛根黄酮（５∶０．

OBJECTIVE: To study the radix puerariae drug carrier systems with ethycellulosepolyethylene glycol (ECPEG). METHODS: The isoflavone drug carrier systems and the art of manufacturing were designed. UV was used to determine the content and dissolution of the samples. RESULTS: The release of isoflavones from loaded beads was influenced by quanlity of EGPEG4000, size of loaded beads and temperature, etc. The optimum ratio of isoflavones, EC and PEG was 1∶5∶0.4, which displayed a dissolution behavior of a quick release followed by a constant slow release with zero order kinetics. Desirable profile of drug release was otained.