金石散对胆道梗阻性胆汁性肝纤维化的防治作用

Prophylactic and Therapeutic Effects of Jin Shi San on Binary Hepatic Fibrosis with Common Duct Obstruction

目的：观察中药金石散对胆汁性肝纤维化的防治效应。方法：大鼠经手术结扎胆总管造成胆道完全梗阻，以血清碱性磷酸酶（s．ALP）、谷丙转氨酸（s．ALT）及肝组织羟脯氨酸（h．HYP）和脱氧核糖核酸（h．DNA）为指标，观察造模同时服用和胆道再通后经口投予金石散的防治效果。结果：胆总管梗阻后及复通后1周时s．ALP、ALT及h．HYP均明显增高，h．DNA明显降低，肝组织呈明显的淤胆及胆汁性肝纤维化病变；而用金石散防治则能显著改善上述变化。结论：金石散对胆总管梗阻引起的肝组织损伤及胆汁性肝纤维化有明显的缓解作用，尤以胆流复通后为佳。

To observe the prophylactic and therapeutic effects of Jin Shi San on binary hepatic fibrosis with common bile duct obstruction. Methods:Through the changes of serum alkalinephosphatase (s-ALP),serum alanine transaminase (s-ALT )and hepatic deoxyribonucleic acid (hDNA) and hepatic hydeoxyproline (h-HYP), at 3weeks after common duct ligation in SD ratscompared with those in normal animals and the groups of Jin Shi San given simultaneously withligation or when relieved one week after ligation to observe the effect of the herbal medicine wasevaluated. Results: s-ALP,s-ALT and h-HYP were increased and h-DNA decreased significantlyat 3 weeks after common duct obstruction and sustained even at one week after the release of theobstruction, while the changes were improved obviously with Jin Shi San used either as treatmentor prevention. Conclusion:The injuries of hepatic tissue induced by common duct ligation wouldbe relieved significantly with Jin Shi San given simultaneously and especially after bile flowrestoration.