经导管介入治疗动脉导管未闭的临床研究

Transcatheter occlusion for patent ductus arteriosus

目的探讨经导管介入封堵治疗动脉导管未闭(PDA)的临床疗效及安全性。方法回顾分析31例接受PDA介入封堵的患者的临床资料,术前经心脏超声筛查,术中、术后测肺动脉压力及主动脉弓造影,术后随访3-12个月。结果31例PDA封堵均成功。封堵后10min,肺动脉压由封堵前的24-96(45.4±20.2)/10-45(21.9±8.6)mmHg,降至13-40(24.9±7.4)/4-23(11.9±5.5)mmHg(P<0.05)。31例经随访均无并发症出现。结论经导管介入封堵治疗PDA创伤小、操作简便、安全有效、并发症少,是单纯PDA的首选方法。

Objective To evaluate the clinical efficacy and safety of transcatheter occlusion for patent ductus arteriosus （PDA）. Methods During Jan. 2008 to Jun. 2009,the clinical data of 31 patients with transcatheter occlusion undergoing PDA were analyzed re- trospectively. Ultrasound examination was performed to find proper septal occluders before operation. The pulmonary artery pressure was determined and aortic arch tomography was performed during and after operation. All cases were followed up for 3 - 12 months. Results All the patent ductus arteriosus were successfully occluded. Systolic pulmonary pressure decreased from （45.4 ±20.2）/（21.9 ± 8.6 ） mmHg to （ 24.9 ± 7.4 ） / （ 11.9± 5.5 ） mmHg at 10 min after transcatheter closure （ P 〈 0.05 ）. After followed up, no complications occurred. Conclusion Transcatheter occlusion is a safe and effective alternative to the surgical repair with less trauma and low complication, and can be a preferred way for PDA.