摘要
以酸性药物萘普生、布洛芬、双氯芬酸、苯丙氨酸和2,4-二氯苯氧基乙酸为研究对象,探讨了酸性药物在微乳液相色谱体系中保留机理,建立了酸性药物的容量因子(k′)与表面活性剂浓度、助表面活性剂浓度、亲脂性有机溶剂浓度以及流动相pH值之间的相关模型。结果表明,表面活性剂、助表面活性剂和亲脂性有机溶剂的浓度以及流动相pH值的变化对酸性药物的容量因子的影响完全与理论模型相吻合。所建立的保留模型能较好地反映在微乳液相色谱体系中微乳液组成和pH值对酸性药物保留行为的影响。
The retention mechanism of acid drugs such as naproxen,ibuprofen,diclofenac,phenylalanine and 2,4-dichlorophenoxy acetic acid in microemulsion liquid chromatography has been discussed.The retention modeling between capacity factors （k＇） of acid drugs in microemulsion liquid chromatography and concentration of surfactant,cosurfactant and lipophilic organic solvent and pH value was set.The results showed the effect of change of concentration of surfactant,cosurfactant and lipophilic organic solvent and pH value on capacity factors of acid drugs in microemulsion liquid chromatography was fully consistent with the theoretical modeling.The retention modeling can better reflect the effect of composition of microemulsion solution and pH value on retention behavior of acid drugs in microemulsion liquid chromatography.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2010年第1期27-32,共6页
Chinese Journal of Analytical Chemistry
关键词
微乳液相色谱
保留模型
保留行为
萘普生
布洛芬
双氯芬酸
苯丙氨酸
2
4-二氯苯氧基乙酸
Microemulsion liquid chromatography
Retention modeling
Retention behavior
Naproxen
Ibuprofen
Diclofenac
Phenylalanine
2
4-Dichlorophenoxy acetic acid
