鼻神经内分泌癌

Nasal neuroendocrine carcinoma

目的研究鼻神经内分泌癌的正确诊断和治疗，以改善其治疗效果。方法对８例鼻神经内分泌癌作了临床分析总结，８例中男７例，女１例；左侧６例，右侧２例；平均病程２．８月，病变范围广泛。单纯放射治疗２例，综合治疗３例，１例已行化学治疗正待放射治疗和手术治疗，２例未治失访。结果经免疫组化和电镜检查证实为神经内分泌癌，其中小细胞型５例，未分化型２例，低分化型１例。１例１年２个月死亡，２例失访，其余仍在治疗随访中。结论本病进展快，预后差，临床治疗中应采用综合治疗方案，单纯手术疗效差。

Objective To recognize and understand further nasal neuroendocrine carcinoma (NNC), improve the diagnosis and therapeutic effect. Methods Eight cases of the nasal neuroendocrine carcinomas (7 males ,1 female) were analyzed . Among them, 6 cases had tumors in left side of nose, 2 in right side. The average course was only 2.8 months, but the lesions were often extent. Results The patients were pathologically confirmed to be neuroendocrine carcinomas. 5 cases were of small cell type, 2 undifferentiated, 1 poorly differentiated. One patient died 14 months after treatment. 2 cases were lost for follow up. The others were still in treatment. Conclusion The nasal neuroendocrine carcinoma has rapid progress and poor prognosis. Clinically, combined treatment should be adopted, the effect of simple operation was poor.