血管通透性因子在鼻息肉中的表达及意义

Expression and significance of vascular permeability factor in nasal polyps

目的探讨血管通透性因子（ｖａｓｃｕｌａｒｐｅｒｍｅａｂｉｌｉｔｙｆａｃｔｏｒ，ＶＰＦ）在鼻息肉组织中的表达及意义。方法将９例鼻息肉标本及８例下鼻甲粘膜标本行ＶＰＦ及其受体ｆｌｋ１的免疫组化染色，光镜观查。结果ＶＰＦ在鼻息肉组织的血管内皮细胞和腺体细胞的表达明显高于下鼻甲组织（Ｐ＜０．０１，Ｐ＜０．０５），ｆｌｋ１在血管内皮细胞的表达明显高于下鼻甲组织（Ｐ＜０．０１）。结论ＶＰＦ对鼻息肉发生过程中组织极度水肿的产生可能有非常重要的作用。

Objective To study the expression and significance of vascular permeability factor(VPF) in nasal polyps. Methods Expression of VPF and its receptor flk 1 in nasal polyps from 9 patients and inferior turbinates from 8 patients with chronic rhinitis were prospectively studied with immunohistochemistry. Each tissue section was observed under optical microscope. Results The VPF positivity in vascular endothelium and in gland cell was significantly higher in nasal polyps than in inferior turbinates ( P < 0.01 and P <0.05, respectively). The flk 1 labeling index of vascular endothelium was significantly higher in nasal polyps than that in inferior turbinates ( P <0.01). Conclusion VPF may play a key role in the formation of heavy edema of nasal polyps.