胰岛素强化治疗对2型糖尿病患者炎症因子的影响

Effects of intensification therapy with insulin on inflammatory factor in patients with type 2 diabetes mellitus

目的观察持续胰岛素皮下输注(CSII)即胰岛素泵治疗和多次皮下胰岛素注射(MSII)对2型糖尿病(T2DM)患者血清炎症因子C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)的影响。方法将116例T2DM患者随机分为A、B 2组,分别给予CSII和MSII强化治疗2周,采用化学发光法测定2组治疗前后血清CRP、TNF-α水平。结果2组强化治疗后,7个时点的指血血糖均较治疗前显著下降(P均<0.001),达标时血糖值分别为(6.49±0.71)mmol/L和(6.98±1.09)mmol/L,A组明显低于B组(P<0.05)。2组CRP水平均显著降低,但2组间比较无显著性差异。2组TNF-α均有下降趋势,但均无显著性差异。结论CSII与MSII均能有效控制T2DM患者的血糖,同时可有效降低血清CRP水平。

Objective It is to observe the effect of continuous hypodermoclysis infusion with insulin （CSII） and repeated hypodermoclysis infusion with insulin （MStl） on serum CRP and TNF-α in patients with type 2 diabetes mellitus （T2DM）. Methods 116 patients with T2DM were randomly divided into group A and B, and they were given intensification therapy with CSII and MSII respectively for two weeks. Serum CRP and TNF - α before and after treatment were determined by chemistry luminescent technique and the difference between the two groups were compared. Results After intensification therapy, blood sugar in singer blood at 7 time points all obviously decreased compared with that before treatment in both groups （ P 〈 0. 001 ）. Blood sugar were （6.49 ± 0.71 ） mmol/L and （6.98 ± 1.09） mmol/L when they reached normal level. Blood sugar in group A was significantly lower than that in group B （ P 〈 0.05）. The levels of CRP in both groups were decreased, but there was no significant difference between the two groups. TNF -α had a decreasing trend in both groups, but no significant difference was found. Conclusion CSII and MSII both can effectively control the blood sugar in patients with T2DM, and can effectively decrease the level of serum CRP.