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灯盏花提取物对移植肾慢性排斥反应的防治作用 被引量:1

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摘要 目的观察灯盏花提取物对移植肾慢性排斥反应的作用,并初步探讨其作用机制。方法应用显微外科技术制作移植肾慢性排斥反应大鼠模型,将24只肾移植大鼠分为对照组、低剂量组和高剂量组三组。分别于术后第4、8和12周检测血清肌酐(sCr)和24 h尿蛋白。术后12周应用非同位素标记法测定外周血T淋巴细胞蛋白激酶C(PKC)活性,ELISA法检测血管内皮生长因子(VEGF)浓度,并行组织学检查。结果灯盏花提取物降低了肾移植后sCr和24 h尿蛋白(P<0.01),减轻了移植肾的病理损伤,降低了PKC活性和VEGF浓度(P<0.01)。结论灯盏花提取物对移植肾组织的功能和结构有保护作用,其可能通过降低T细胞PKC活性和减少VEGF的表达延缓移植肾慢性排斥反应的发生。
出处 《山东医药》 CAS 北大核心 2010年第1期26-27,共2页 Shandong Medical Journal
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参考文献7

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