无创动脉硬化检测评价血压对动脉硬化影响的研究

Study on evaluating impact of blood pressure on atherosclerosis by non-invasive arteriosclerosis detection

目的探讨心-踝血管指数(CAVI)和踝臂指数(ABI)在健康人群和动脉粥样硬化性疾病及其危险因素人群中血管早期病变评价中的临床应用价值,在临床工作中更好地防治动脉粥样硬化性疾病。方法随机选择心内科住院的110例动脉粥样硬化性疾病患者或具有动脉粥样硬化性疾病危险因素者入选动脉粥样硬化组,对照组系同期在该科住院血压正常患者100例,采用VS-1000型血压脉搏测量仪检测210例患者的CAVI和ABI数值。左室射血分数(LVEF)检测采用HP-SONO5500型彩色多普勒超声显像仪。结果与健康对照组相比,动脉粥样硬化组CAVI明显升高,差异有统计学意义(P<0.001);ABI动脉粥样硬化组与正常血压组相比明显降低,差异有统计学意义(P<0.001);但左右两组相比差异均无统计学意义(P>0.05)。LVEF动脉粥样硬化组较正常血压组明显降低,差异有统计学意义(P=0.031)。相关性分析显示,动脉粥样硬化组CAVI与LVEF呈正相关(r=0.612,P<0.05),ABI与CAVI呈负相关(r=-0.697,P<0.001)。健康组上述各指标之间均无明显相关性。结论血压的变化对动脉硬化的发病有一定影响,而CAVI和ABI的检测在健康人群和动脉粥样硬化性疾病及其危险因素人群中对于血管早期病变评价有重要的临床应用价值。

Objective To explore the clinical application valure of cardio-ankle vascular index（CAVI） and ankle-brachial index （ABI） for evaluating early vascular diseases in healthy population,atheroselerosis patients and high risk population in order to better prevent and treat atheroselerosis in clinic. Methods To randomly select 100 hospitalized patients with atherosclerosis or risk factor of atherosclerosis as the atherosclerotic group. The other CVAI and ABI in two groups were detected by type VS-1000 blood and pulse measuring instrument. Left ventricular ejection fraction（LVEF） was detected by HP-SONO5500 color Doppler ultrasound imaging instrument. Results Compared with the healthy control group,CAVI in the atherosclerotic group increased obviously with statistical difference（P〈0. 001）;ABI decreased significantly compared with the normal blood pressure group with statistical differ ence（left side P〈0. 001;right side P〈0.01 respectively）, but there was no statistical difference between the left side and right side groups（P〉0.05）. Correlation analysis showed that CAVI in the atherosclerotic group was positively correlated with LVEF（r=0. 612 ,P〈0. 015）,ABI was negatively correlated with AVt（r=-0. 697 ,P〈0. 001）. No significant correlation existed among the above indexes in the healthy control group. Conclusion The change of blood pressure have certain influence on the pathogenesis of atherosclersis. Detection of CAVI and ABI in healthy population, atherosclerosis patients and high risk population has important value for evaluating early vascular diseases.