纳米La_2O_3/TiO_2复合薄膜的抗凝血性研究

Study of Antithrombus Properties of La_2O_3-TiO_2 Nanocomposite Films

采用射频磁控溅射方法制备了TiO2薄膜和La2O3掺杂的TiO2复合薄膜。利用扫描电子显微镜、X射线衍射,紫外可见光谱等材料表征方法研究La2O3掺杂对TiO2薄膜的结构及抗凝血性能的影响。结果表明:La2O3掺杂促使TiO2晶粒沿金红石相(110)晶面择优生长,能细化TiO2纳米晶粒的大小,使薄膜的光学带隙由2.85 eV提高到3.2 eV。血小板粘附实验表明La2O3掺杂的TiO2复合薄膜具有优良的血液相容性能;分析了复合薄膜的抗凝血机理。

TiO2and La2O3 doped TiO2 films were deposited by means of the Radio-Frequency magnetron sputtering technique. The influences of doping La2O3 on the microstructure, optical properties and blood compatibility of TiO2film were investigated by using X-ray diffraction （XRD）, scanning electron microscopy （SEM）, UV-visible optical absorption spectroscopy and tests of platelet adhesion, respectively. Results show that doping La2O3 is beneficial to the preferential growth of the （110） plane of rutile phase and can refine grain size of TiO2, resulting in an increase of optical band gap from 2. 85 to 3.2eV. The quantity and morphology of the adherent platelets on the surface of samples indicated that La2O3 doped TiO2film is potentially useful biomaterials with good blood compatibility. The mechanism of haemocompatibility of TiO2film doped La2O3 was analyzed and discussed.