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和肽素检测的临床应用研究进展 被引量：3

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摘要 和肽素（copeptin）是AVP前体羧基末端的一段多肽，两者都是从同一个前体剪切下来的多肽片段。AVP又称抗利尿激素，在下丘脑视七核、室旁核神经元内合成，其最初产物为前激素原，进入高尔基体内形成精氨酸加压素原，后者由164个氨基酸组成，在酶的作用下最终分解为3个多肽片段释放入血液中。AVP是含9个氨基酸残基的多肽，
作者 曹文革
机构地区 吉林省辽源市中心医院检验科
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2010年第1期84-85,共2页 Chinese Journal of Laboratory Medicine
关键词 多肽片段 临床应用 抗利尿激素 检测 精氨酸加压素 氨基酸组成 氨基酸残基 AVP
分类号 R446.1 [医药卫生—诊断学]
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参考文献14

  • 1Barat C, Simpson L, Breslow E. Properties of human vasopressin precursor constructs : inefficient monomer folding in the absence of copeptin as a potential contributor to diabetes insipidus. Biochemistry, 2004,43 : 8191-8203.
  • 2李春盛,田茹敏,高秀兰,李爱民,齐平.急性心肌梗塞患者血浆内阿片肽和精氨酸加压素含量及其临床意义[J].中国危重病急救医学,1996,8(5):287-289. 被引量：9
  • 3Valli G, Fedeli A, Palange P, et al. Water and sodium imbalance in COPD patients. Monaldi Arch Chest Dis, 2004, 61:112-116.
  • 4Stefan-Jochberger MD, Morgenthaler NG, Mayr VD, et al. Copeptin and arginine vasopressin concentrations in critically ill patients. Clin Endocrinol Metab, 2006,91:43814386.
  • 5Bhandari SS, Loke I, Davies JE, et al. Gender and renal function influence plasma levels of eopeptin in healthy individuals. Clin Sei, 2009,116:257-263.
  • 6Morgenthaler NG, Struck J, Bergmann A, et al. Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem, 2006,52 : 112-119.
  • 7Katan M, Morgenthaler NG, Dixit KC, et al. Anterior and posterior pituitary function testing with simultaneous insulin tolerance test and a novel copeptin assay. Clin Endocrinol Metab, 2007,92:2640-2643.
  • 8Fenske W, Stork S, Bleehschmidt A, et al. Copeptin in the differential diagnosis of hyponatremia. Clin Endocrinol Metab, 2008,94 : 123-129.
  • 9Katan M, Morgenthaler N, Widmer I, et al. Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level. Neuro Lett, 2008,29 : 341-346.
  • 10Muller B, Morgenthaler N, Stolz D, et al. Circulating levels of copeptin, a novel biomarker, in lower respiratory tract infections. Eur J Clin Invest, 2007,37 : 145-152.

二级参考文献3

共引文献8

同被引文献42

  • 1Steg PC., James SK, Atar D, et al.ESU Gmuennes for the management of acute myocardial infarction in pa- tients presenting with ST-segment elevation: The Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC). Eur Heart J, 2012, 33 (20): 2569-2619.
  • 2Coviello I, Pinnacchio G, Laurito M, et al. Prognostic role of heart rate variability in patients with ST-segment elevation acute myocardial infarction treated by primary angioplasty. Cardiology, 2013, 124 (1): 63-70.
  • 3Kosuge M, Kimura K. Clinical implications of electrocardiograms for patients with anterior wall ST-segment elevation acute myocardial infarction in the interventional era. Circ J, 2012, 76 (1): 32-40.
  • 4Jochberger S, Morgenthaler NG, Mayr VD, et al. Copeptin and arginine vasopressin concentrations in critically ill patients. J Clin Endocrinol Metab, 2006, 91 (11): 4381-4386.
  • 5Mastropietro CW, Mahan M, Valentine KM, et al. C- opeptin as a marker of relative arginine vasopressin deficiency after pediatric cardiac surgery. Intensive Care Med, 2012, 38 (12): 2047-2054.
  • 6Yi SS, Kim H J, Do SG, et al. Arginine vasopressin (AVP) expressional changes in the hypothalamic paraventricular and supraoptic nuclei of stroke-prone spontaneously hypertensive rats. Anat Cell Biol, 2012, 45 (2): 114-120.
  • 7Liebetrau C, Nef H, Szardien S, et al. Release kinetics of eopeptin in patients undergoing transcoronary ablation of septal hypertrophy. Clin Chem, 2013, 59 (3): 566-569.
  • 8Boertien WE, Meijer E, Li J, et al. Relationship of copeptin, a surrogate marker for arginine vasopressin, with change in total kidney volume and GFR decline in autosomal dominant polycystic kidney disease: results from the CRISP cohort. Am J Kidney Dis, 2013, 61 (3): 420-429.
  • 9Keller T, Tzikas S, Zeller T, et al. Copeptin improves early diagnosis of acute myocardial infarction. J Am Coil Cardiol, 2010, 55 (19): 2096-2106.
  • 10Reichlin T, Hochholzer W, Stelzig C, et al. Incremental value of copeptin for rapid rule out of acute myocardial infarction. J Am Coll Cardiol, 2009, 54 (1): 60-68.

引证文献3

二级引证文献12

中华检验医学杂志
2010年 第1期

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