2007～2008年温州地区急性呼吸道感染病毒病原学研究

Viral etiology of acute respiratory infection in children from Wenzhou between 2007 and 2008

目的分析2007～2008年温州地区急性呼吸道感染病毒病原学的检测结果,为临床提供病毒病原学诊断依据。方法取5097例急性呼吸道感染儿童鼻咽分泌物,采用直接免疫荧光法检测7种常见呼吸道病毒抗原。结果①2209份标本(43.3%)病毒病原检测阳性,其中呼吸道合胞病毒(RSV)1725例(78.1%),腺病毒(ADV)61例(2.8%),流感病毒A型(IVA)66例(3.0%),流感病毒B型(IVB)12例(0.5%),副流感病毒1型(PIV1)38例(1.7%),副流感病毒2型(PIV2)7例(0.3%),副流感病毒3型(PIV3)275例(12.4%);②病毒检出率在小于3个月和小于6个月年龄组较高,分别为53.6%和49.2%;③冬季病毒检出率最高。结论2007～2008年温州地区急性呼吸道感染的病毒仍以RSV为主要病原体,<6个月的婴幼儿病毒感染率较高,好发于冬季。

Objective To study the viral etiology of acute respiratory infection （ARI）in children from Wenzhou, Zhejiang between 2007 and 2008. Methods The nasopharyngeal aspirate samples were obtained from 5 097 hospitalized children with ARI. Seven common respiratory viruses, including respiratory syncytial virus （RSV） , influenza virus A and B, parainfluenza viruses 1,2 and 3 and adenovirus, were detected using direct immunofluorescence. Results Viral agents were identified in 2 209 cases （43.3%）. Of the 2 209, RSV was the most frequent （78.1%）, followed by parainfluenza 3 （ 12.4% ）, influenza virus A （3.0%）, adenovirus （2.8%）, parainfluenza 1 （ 1.7% ）, influenza B （0.5%） and parainfluenza 2 （0.3 % ）. The infants at ages of 〈 3 months and 〈 6 months had higher detection rate of viruses （53.6% and 49.2%, respectively）. A highest detection rate of viruses was found in winter. Conclusions RSV is the leading pathogen of ARI in children from Wenzhou, Zhejiang between 2007 and 2008. The children at age of less than 6 months are susceptible to respiratory viruses. The viral activity peaks in winter.