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氯法拉滨在血液系统恶性肿瘤治疗中的应用 被引量：2

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摘要 急性白血病是儿童以及成人常见的血液恶性肿瘤之一，近年来由于支持治疗以及化疗方案的改进，在儿童急性淋巴细胞白血病（ALL）5年无病生存（DFS）率达80％以上，急性髓系白血病（AML）5年DFS率达40％，成人ALL患者长期生存率则低于30％。
作者 路瑾 黄晓军
机构地区 北京大学人民医院、北京大学血液病研究所
出处 《中华血液学杂志》 CAS CSCD 北大核心 2010年第1期66-68,共3页 Chinese Journal of Hematology
关键词 恶性肿瘤治疗 儿童急性淋巴细胞白血病 血液系统 急性髓系白血病 血液恶性肿瘤 急性白血病 长期生存率 化疗方案
分类号 R733 [医药卫生—肿瘤]
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参考文献23

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同被引文献35

  • 1夏敏,蒋慧.儿童急性白血病治疗新药氯法拉滨[J].世界临床药物,2007,28(6):356-359. 被引量：11
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  • 5Zhenchuk A, Lotfi K, Juliusson G, et al. Mechanisms of anticancer action and pharmacology of clofarabine [ J ]. Biochem Pharmacol, 2009, 78(11 ): 1351-1359.
  • 6Bonate PL, Arthaud L, Cantrell WR Jr, et al. DiscovexT and development of clofarabine: a nueleoside analogue for treating cancer [J]. Nat Rev Drug Discov, 2006, 5(10): 855-863.
  • 7Reichelova V, Liliemark J, Albertioni F, et al. Liquid chromatographic study of acid stability of 2-chloro-2'-arabino- fluoro- 2'-deoxyadenosine, 2-chloro-2'-deoxyadenosine and related analogues [ J].J Pharm Biomed Anal, 1995, 13 (4-5) : 711-714.
  • 8Xie C, Plunkett W. Metabolism and actions of 2-ehloro-9-(2-deoxy-2- fluoro-beta-D-arabinofuranosyl)-adenine in human lymphoblastoid cells[J]. Cancer Res, 1995, 55(13): 2847-2852.
  • 9King KM, Damaraju VL, Vickers MF, et al. A comparison of the transportability, and its role in cytotoxicity, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems [Jl. Mol Pharmacol, 2006, 69 ( 1 ) : 346-353.
  • 10Chen LS, Plunkett W, Gandhi V. Polyadenylation inhibition by the triphosphates of deoxyadenosine analogues [ J ]. Leuk Res, 2008, 32(10) : 1573-1581.

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中华血液学杂志
2010年 第1期

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