小檗碱对高脂饲料所致大鼠非酒精性脂肪肝的保护作用

Protective Effect of Berberine on the Nonalcoholic Fatty Liver Induced by High-Fat Diet in Rats

目的:观察小檗碱对高脂饲料所致非酒精性脂肪肝的影响。方法:采用高脂饲料建立大鼠脂肪肝模型,治疗组分别灌胃给予小檗碱100和200 mg/kg。4周后,处死动物,检测肝指数、抗氧化功能、血清及肝脏中脂质含量等指标。结果:小檗碱能改善大鼠肝指数,明显降低血清及肝匀浆中甘油三酯含量,下调血清游离脂肪酸含量,提高肝匀浆超氧化物岐化酶活性。结论:小檗碱对高脂饲料所致大鼠非酒精性脂肪肝具有一定的保护作用,其机制与调节血脂、提高肝脏抗氧化能力有关。

Objective： To observe the protective effects of berberine on nonalcoholic fatty liver induced by high-fat diet in rats. Methods： Fatty liver disease model was established by feeding rats with high-fat diet. The therapeutic groups were administered with berberine by gavage at the dose of 100 and 200 mg/kg daily. After four weeks, all rats were sacrificed. Liver index, anti-oxidative function, blood and liver lipid were assayed. Results： Berberine decreased the liver index, re duced the content of serum and hepatic triglycerides, lowered the serum free fatty acid level, and increased liver homogenate SOD activity of rats with fatty liver. Conclusion： Bererine can protect rats from nonalcoholic fatty liver disease induced by high-fat diet maybe through lowering blood lipid level and improving hepatic anti-oxidative capability.