胃癌术后复发59例分析

Postoperative Recurrence in Gastric Cancer:Analysis of 59 Cases

目的:回顾性分析我科胃癌术后复发与主要临床病理特征的关系,重点探讨术后复发时间及其相关因素。方法:在286例胃癌术后病人中,分析有完整随访信息的59例复发患者的临床数据,研究复发时间及其与临床分期和和辅助化疗的关系。结果:76.3%(45/59)的病人在术后1年内复发,中位复发时间为7个月(1-60个月),57.6%(34/59)为局部-区域复发。Ⅰ-Ⅳ期病人之间复发时间的差异无统计学意义(P>0.05,Kruskal-Wallis检验)。不同的辅助化疗周期数之间的复发时间的差异有显著性(P<0.05,Kruskal-Wallis检验)。结论:胃癌病人术后2年内是监测随访重点,辅助化疗有助于延长无复发生存。

Objective： To elucidate the relationship of cancer recurrence with major clinico-pathological factors, with special attention focusing on time to recurrence. Methods： Data of 59 recurrences after surgery from 286 cases of gastric cancer were systematically collected and analyzed. Time to recurrence was analyzed in relation to the clinical staye and the adjuvant chemotherapy cycles of patients. Results： Of all the recurrence, 76.3% （45/59） happened within one year after surgery, median time to recurrence was seven months （1-60 months）, and 57.6% （34/59） were loco-regional recurrence. The differences in time to recurrence among stages I , II , Ⅲ , and IV were statistically not significant （P〉0.05, Kruskal-Wallis Test）. There were significant differences among different adjuvant chemotherapy cycles in time to recurrence （P〈0.05, Kruskat-Wallis Test）. Conclusion： Close monitoring and active follow-up of patients with gastric cancer should be conducted over the first two years after operation. Adjuvant chemotherapy could prolong recurrence-free survival.