摘要
在体内乙醇代谢过程中起重要作用的酶有乙醇脱氢酶(ADH)、乙醛脱氢酶(ALDH)和细胞色素P4502E1酶(CYP2E1),它们均具有基因多态性,不同基因型个体对乙醇的耐受性存在差别,表现为酒后的行为反应能力不同。司机若为慢代谢型,乙醇、乙醛代谢速率低下,即使少量饮酒,酒后开车也可造成交通肇事。通过对ADH、ALDH和CYP2E1基因多态性与乙醇、乙醛代谢能力的关系进行综述。
Alcohol dehydrogenase （ADH）, acetaldehyde dehydrogenase （ALDH） and cytochrome P450 2El （CYP2E1） with gene polymorphism play important roles in alcohol metabolism in vivo. Individuals with distinct genotypes are different in alcohol tolerance and show unequal behavioral responses after drinking. Poor metabolism of alcohol and acetaldehyde in blood will low individual＇ s capability of judgment and may lead to traffic accidents. This article reviews the relationship of gene polymorphism of ADH, ALDH and CYP2E1 and the metabolism capability of alcohol and acetaldehyde.
出处
《中国司法鉴定》
北大核心
2010年第1期30-32,共3页
Chinese Journal of Forensic Sciences
关键词
乙醇
乙醛
代谢
交通事故
ethano
acetaldehyde
metabolism
traffic accident
