摘要
CYP2C19是细胞色素氧化酶P450的主要成分之一,因其活性存在显著的个体差异,表现为遗传多态性,从而产生血药浓度的个体差异。本文对CYP2C19基因型与奥美拉唑代谢、临床疗效及CYP2C19新突变对奥美拉唑的影响进行综述,根据基因型设计奥美拉唑给药方案,为临床实行个体化给药、提高疗效、减少不良反应提供参考。
CYP2C 19 is one of the important cytochrome oxidase P450, the activity of which shows genetic polymorphism, manifesting different plasma concentrations in different individuals.New advances including the relationship between CYP2C19 gene polymorphism and metabolism of omeprazole, its clinical efficacy, and the effect of new mutation of CYP2C19 on omeprazole were reviewed.The dosage regimen was established on the basis of the CYP2C19 genotypes, which could provide reference for implementing individual medication, improving clinical efficacy and decreasing the occurrence of adverse drug reactions.
出处
《中国药物应用与监测》
CAS
2010年第1期55-57,共3页
Chinese Journal of Drug Application and Monitoring
基金
2008年深圳市科技计划项目课题(200803001)
