血管紧张素Ⅱ受体阻断剂治疗高血压合并肾损害的机制及其临床应用

Therapeutic mechanism of angiotensinⅡreceptor blockers and their clinical application in the treatment of hypertension combining renal disfunction

血管紧张素Ⅱ受体阻断剂(ARB)具有独立于降压作用之外的良好的肾脏保护作用,不仅能有效降低血压,还能降低糖尿病患者的尿蛋白,延缓其肾病进展,是目前市场上非常有潜力的降压药物之一。本文综述近年ARB用于高血压合并肾损害的作用机制、疗效评价以及临床应用。

Angiotensin Ⅱ receptor blockers （ARB） are widely applied for controlling blood pressure. The animal experiments and clinical studies have showed that ARB can reduce the risk of cardiovascular diseases and protect the renal function with less adverse reactions. ARB as a kind of hypotensive drug is of enormous potential in market.This review described the mechanism of ARB and its clinical application in the treatment of hypertension combining renal disfunction.