脑梗死与颈动脉粥样硬化斑块及其相关因素分析

Analysis on cerebral infarction and carotid atherosclerotic plaque

目的探讨脑梗死与颈动脉粥样硬化(CAS)斑块及血脂、纤维蛋白原(Fbg)水平的关系。方法对96例经头CT或MRI确诊的急性脑梗死患者和43例对照组进行颈动脉颅外段彩色多普勒检查,观察斑块情况。同时检测2组血脂、纤维蛋白原水平。结果(1)病例组96例,斑块检出率为78.13%(75/96)。对照组为18.60%(8/43)(P<0.01);(2)血清总胆固醇(TC)、低密度脂蛋白(LDL)及Fbg水平脑梗死组明显高于对照组(P<0.05);脑梗死组有斑块亚组明显高于无斑块亚组(P<0.05)。结论颈动脉硬化斑块与脑梗死发生有密切关系,不稳定颈动脉硬化斑块是脑梗死发生的重要因素。LC,LDL,Fbg水平增高是脑梗死及颈动脉粥样硬化斑形成的危险因素。

Objective To investigate the relationships among cerebral infarction （CI） and carotid atherosclerosis （CAS） plague, levels of plasma lipid and Fbg. Methods Ninety-six patients with CI were detected by color Doppler and the levels of plasma lipid and fibrinogen （Fbg） were evaluated, and compared with 43 patients in normal control （NC） group. Results Rate of plague in CI group was 78.13 % （75/96） which was significantly higher than 18.60% （8/43）of NC Group（P〈0.0l ） ;The levels of total cholesterol （TC）, low density lipoprotein （LDL） and Fbg in CI group were significant higher than those in NC group （P〈0. 05）, and in CI with plaque subgroup were significantly higher than those in CI without plaque subgroup （P〈 0.05）. Conclusion CAS plague has a close relationship with CI, unstable CAS plague is a key factor of the occurrence of CI. High levels of LC, LDL and Fbg are risk factors of CI and CAS.