阿司匹林联合氯吡格雷治疗短暂性脑缺血发作疗效观察

Observation of curative effect of aspirin and clopidogrel in transient ischemic attack

目的观察阿司匹林联合氯吡格雷治疗短暂性脑缺血发作(TIA)的疗效和安全性。方法选择本院住院的65例TIA患者33例,给予阿司匹林及氯吡格雷为治疗组,32例予口服肠溶阿司匹林为对照组,均持续3个月。结果随访3个月,治疗组33例T1A发作在10d内完全控制无复发32例,有效率96.97%(32/33),无1例发展为脑梗死,无出血并发症。对照组32例TIA发作完全控制18例,有效率56.25%(18/32),有11例发展为脑梗死。2组比较有显著性差异(P<0.001)。结论阿司匹林联合氯吡格雷治疗TIA安全有效,不易复发,无明显不良反应。

Objective To observe the effect and safety of aspirin and clopidogrel in treating transient ischemic at- tack. Methods Sixty-five patients with TIA were enrolled in this study and distributed into treatment group and control group. Treatment group was administered aspirin and clopidogrel, control group was given aspirin. Results TIA attacks were controlled completely within 10 days in treatment group,no re-attacks in 32 cases after 3 months＇ follow-up（32/33） ,the efficacy rate reached up to 96.7G ,no one developed cerebral infarction and cerebral hemorrhage. In control group, TIA attacks were controlled completely in 18 of 32 cases（56.25 %）, 9 patient developed cerebral infarction. There was a significant differences between the two group（P〈0. 001）. Conclusion Aspirin and clopidogrel are effective and safe in the treatment of TIA,the reoccurrence rate is low and there is no obvious drug side effect.