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糖原合成酶激酶-3β与心血管疾病 被引量：1

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摘要 糖原合成酶激酶-3β(GSK-3β)是一种丝氨酸/苏氨酸蛋白激酶,大量的实验研究证明GSK-3β与缺血-再灌注损伤密切相关,缺血预处理、后处理及许多心肌保护药物被认为都是通过调节GSK-3β来发挥他们的心肌保护作用,而且GSK-3β被认为是一个心肌肥大的负调节因子。鉴于GSK-3β与心血管疾病的密切相关性。该文将GSK-3β在缺血-再灌注损伤及心肌肥大中的作用及其机制作一综述。
作者 白宝宝 陶谦民 夏强
机构地区 浙江大学医学院附属第一医院心血管内科 浙江大学医学院生理学教研室
出处 《国际心血管病杂志》 2010年第1期24-26,共3页 International Journal of Cardiovascular Disease
关键词 糖原合成酶激酶-3Β 缺血-再灌注 心力衰竭 心肌肥大
分类号 R54 [医药卫生—心血管疾病]
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参考文献18

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同被引文献12

  • 1Srivastava G,Mehta JL. Currying the heart:curcumin and cardioprotection[J].Journal of Cardiovascular Pharmacology and therapeutics,2009,(01):22-27.
  • 2Chanoit G,Lee S,Xi J. Exogenous zinc protects cardiac cells from reperfusion injury by targeting mitochondrial permeability transition pore through inactivation of glycogen synthase kinase3beta[J].American Journal of Physiology-Heart and Circulatory Physiology,2008,(03):H1227-H1233.
  • 3Zhou H,Beevers CS,Huang S. The targets of curcumin[J].Current Drug Targets,2011,(03):332-347.
  • 4Forde JE,Dale TC. Glycogen synthase kinase 3:a key regulator of cellular fate[J].Cellular and Molecular Life Sciences,2007,(15):1930-1944.doi:10.1007/s00018-007-7045-7.
  • 5Jope RS,Johnson GV. The glamour and gloom of glycogen synthase kinase-3[J].Trends in Biochemical Sciences,2004,(02):95-102.doi:10.1016/j.tibs.2003.12.004.
  • 6Vasileva AK,Plotnikov EY,Kazachenko AV. Inhibition of GSK-3β decreases the ischemiainduced death of renal cells[J].Bulletin of Experimental Biology and Medicine,2010,(03):303-307.
  • 7Cuzzocrea S,Mazzon E,Esposito E. Glycogen synthase kinase-3beta inhibition attenuates the development of ischemia/reperfusion injury of the gut[J].Intensive Care Medicine,2007,(05):880-893.doi:10.1007/s00134-007-0595-1.
  • 8Collino M,Thiemermann C,Mastrocola R. Treatment with the glycogen synthase kinase3beta inhibitor,TDZD-8,affects transient cerebral ischemia/reperfusion injury in the rat hippocampus[J].Shock,2008,(03):299-307.doi:10.1097/SHK.0b013e318164e762.
  • 9Gao HK,Yin Z,Zhou N. Glycogen synthase kinase 3 inhibition protects the heart from acute ischemia-reperfusion injury via inhibition of inflammation and apoptosis[J].Journal of Cardiovascular Pharmacology and therapeutics,2008,(03):286-292.
  • 10Zhai P,Sciarretta S,Galeotti J. Differential roles of GSK-3β during myocardial ischemia and ischemia/reperfusion[J].Circulation Research,2011,(05):502-511.

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国际心血管病杂志
2010年 第1期

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