氯吡格雷联用阿托伐他汀预防高危患者脑梗死再发前瞻性研究

Effects of Clopidogrel Combined with Atorvastatin on Preventing Relapsed Cerebral Infarction in high-risk Patient

目的:氯吡格雷联用阿托伐他汀预防高危脑梗死患者,观察1年内脑梗死再发率。方法:随机选取2007年12月至2008年12月期间我科收治疗100例确诊的脑梗死患者,且ESRS(Essen卒中风险评分量表)≥3分,随机分为两组,治疗组50例,口服氯吡格雷75mg+阿托伐他汀20mg,每天一次,对照组50例,单用氯吡格雷75mg每天一次,进行随访1年。对比两组脑梗死再发率及不良反应,并作统计学分析。结果:治疗组脑梗死复发率明显少于对照组(P<0.05)。结论:氯吡格雷联用阿托伐他汀降低脑梗死复发率明显优于常规治疗,疗效显著,且安全可靠。

Objective： To study the effect of clopidogrel combined with atorvastatin on preventing relapsed cerebral infarction in high -risk patient. Method： 100 inpatients which were diagnosed as cerebral infarction in our hospital from 2007. 12 to 2008. 12 were included. The included patients which of ESRS scores were more than 3 point were randomly divided into 2 groups. 50 patients in treatment group accepted clopidogrel 75mg and atorvastatin 20mg Once a day. 50 patients in control group accepted clopidogrel 75mg once a day. All the patents were followed up for 1 year, and the rate of relapsed cerebral infarction and adverse effect were recorded. Result： Compared with control group, the rate of relapsed cerebral infarction was decreased in treatment group （ p 〈 0.05 ）. Conclusion： Compared with clopidogrel, clopidogrel combined with atorvastatin may have better effects in preventing relapsed cerebral infarction, also safe reliable.