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基于GO的酵母膜系统蛋白相互作用规律研究

Study on Protein-protein Interactions of S.cerevisiae Membranes Based on Gene Ontology
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摘要 引进描述蛋白质相互作用倾向性参数(PIRB),基于GO(Gene Ontology)和相关的数据库中蛋白质功能注释,对酿酒酵母部分膜蛋白相互作用规律进行了研究,构建了基于PIRB的蛋白质相互作用网络图.结果表明各类膜蛋白质之间的相互作用具有明显的偏向性.对这种偏向性的生物学含义作了简要探讨. A parameter PIRB describing protein-protein interaction bias was defined. The law of S. cerevisiaets membrane proteins interacting was investigated based on the Gene Ontology （GO） and the GO annotation from a related database. The protein-protein interaction network based on PIRB was constructed. The results indicate that there exists obvious interaction bias among proteins. The biological implication was also been discussed briefly.
作者 蔡禄 裴智勇 季风 江威
机构地区 内蒙古科技大学数理与生物工程学院 内蒙古科技大学生物工程与技术研究所
出处 《内蒙古大学学报（自然科学版）》 CAS CSCD 北大核心 2010年第1期85-90,共6页 Journal of Inner Mongolia University：Natural Science Edition
基金 国家自然科学基金资助项目(60761001)
关键词 蛋白质相互作用 基因本体 相对倾向性因子 膜蛋白 酿酒酵母 protein-protein interactions （PPI） Gene Ontology protein-protein interactions relative bias （PIRB） membrane proteins S. cerevisiae
分类号 Q61 [生物学—生物物理学]
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参考文献14

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二级参考文献35

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共引文献12

内蒙古大学学报（自然科学版）
2010年 第1期

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