血清降钙素原在小儿哮喘急性发作中的临床意义

Significance of serum procalcitonin in acute onset of children asthma

目的:探讨通过测定血清降钙素原(proealeitonin,PCT)来指导哮喘急性发作患儿临床抗生素应用的意义。方法:将支气管哮喘急性发作患儿342例随机分成两组,一组使用抗生素(抗生素组),另一组不用抗生素(对照组)。根据PCT结果对两组阳性患者及阴性之间相比较,并进行结果分析。结果:应用PCT方法检测出的细菌感染患儿总检出率为89%。两组中细菌性重症肺炎并哮喘急性发作的患者,PCT阳性检出率为100%。两组中PCT阴性患儿3d疗效结果显示,抗生素组差异无统计学意义(P>0.05);而两组中PCT阳性患儿3d疗效结果显示,抗生素组完全缓解和部分缓解疗效与对照组比较,差异有统计学意义(P<0.01)。结论:PCT的检测对于鉴别哮喘急性发作中细菌性感染和非细菌感染患儿具有一定的临床应用价值。

Objective： To discuss the significance of serum procalcitonin （PCT） in antibiotics selection for acute onset of children asthma. Methods： 342 children with acute asthma were randomly divided into antibiotic group and control group which were treated with antibiotics and without antibiotics separately. All the patients underwent PCT test and were marked as PCT-negative or PCT-positive. Compare the therapeutic effects of these two groups. Results： According to PCT test, 89% patients got bacterial in- fection, all sever cases complicated with pneumonia in both groups were tested as PCT-positive （100%）. After 3 days of treatment, there was no significant difference between the therapeutic effects of PCT-negatire cases in both antibiotic group and the control （P〉0.05）, while for the PCT-positive cases in the two groups, both the complete relief rate and the partial relief rate were significant different from each other. Conclusion： PCT test can help to differentiate bacterial infections from non-bacterial infections in acute onset of children asthma.