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阿托伐他汀对稳定型心绞痛患者冠状动脉介入治疗术后内皮微粒的影响 被引量：2

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摘要 目的评价阿托伐他汀对稳定型心绞痛(SAP)行冠状动脉介入治疗(PCI)患者循环血中内皮微粒(EMP)和可溶性细胞间黏附分子-1(sICAM-1)的影响。方法将初诊慢性稳定型心绞痛行PCI治疗的患者56例随机分为阿托伐他汀组和对照组,阿托伐他汀组于计划行PCI前7 d开始给予阿托伐他汀40 mg/d治疗。于阿托伐他汀治疗前、PCI后24 h采集静脉血,采用流式细胞术测定患者血浆EMP水平,酶联免疫吸附法测定血清sI-CAM-1水平。结果两组在阿托伐他汀治疗前EMP和sICAM-1水平无统计学差异(P>0.05);PCI后24 h阿托伐他汀组EMP和sICAM-1水平均明显低于对照组(P<0.05)。EMP与sICAM-1呈显著正相关(rs=0.854,P<0.01)。结论阿托伐他汀可明显降低SAP患者PCI术后EMP和sICAM-1水平;EMP可作为评价PCI术后冠脉内皮炎症反应和损伤程度的指标。
作者 陆永光 文宏 苏波 钟继明 苏强
机构地区 广西心血管病研究所广西医科大学第一附属医院
出处 《山东医药》 CAS 北大核心 2009年第49期50-51,共2页 Shandong Medical Journal
关键词 阿托伐他汀 心绞痛 血管成形术 经腔 经皮冠状动脉 内皮微粒 血管细胞黏附分子-1
分类号 R541 [医药卫生—心血管疾病]
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参考文献7

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同被引文献38

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山东医药
2009年 第49期

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