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转录因子Blimp1蛋白的研究现状

Research Progress of B Lymphocyte Induced Maturation Protein 1 Blimp1
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摘要 Blimp1蛋白作为锌指蛋白转录抑制因子,其促进B细胞发育成浆细胞终末分化中的作用已被大家共识。最近的研究显示,此蛋白在B细胞发育中起维持作用、在T细胞发育中起诱导分化作用,及在B细胞淋巴瘤中起抑癌因子作用。在小鼠及其他动物的胚胎发育中,Blimp1蛋白在原始干细胞发育、肌肉组织的形成等方面的作用也得到了人们初步的认识。 B lymphocyte induced maturation protein 1（Blimp1）is a zinc finger transcriptional repressor,the role of Blimp1 as a main regulator of terminal differentiation of B cells into plasma cells has been well studied.Recently,new roles for Blimp-1 have been revealed,as a key regulator of B cell development and T-cell differentiation and as a suppressor of B cell lymphoma.In the embryonic development of mice and other animals the roles of Blimp1 protein in the development of primitive stem cells,and in the formation of muscle tissue have been preliminary understood.
作者 宋艳 张询
机构地区 中国医学科学院协和医科大学肿瘤医院肿瘤研究所病理科
出处 《医学综述》 2010年第1期42-44,共3页 Medical Recapitulate
关键词 Blimp1 原始干细胞 抑癌基因 淋巴细胞 Blimp1 Primitive stem cells Tumor suppressor gene Lymphocyte
分类号 R392 [医药卫生—免疫学]
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参考文献25

  • 1Keller AD, Maniatis T. Identification and characterization of a novel repressor of beta-interferon gene expression[ J]. Genes Dev, 1991, 5(5) :868-879.
  • 2Turner CA, Mack DII, Das MM. Blimpl, a novel zinc finger-containing protein that cart drive the maturation of B lymphocytes into immunoglobulin secreting cells [ J ]. Cell, 1994,77 ( 2 ) :297-306.
  • 3Tunyaplin C, Shapiro MA, Catamc KC, et al. Characterization of the B lymphocyte-induced maturation protein ( Blimpl ) gene, mRNA isoforms and basal promoter [ J ]. Nucleic Acids Res, 2000,28 (24) :4846-4855.
  • 4Gyory I, Fejer G, Ghosh N ,et al. Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines [ J ]. J Immunol, 2003,170 ( 6 ) : 3125-3133.
  • 5John SA, Garrett-Sinha LA. Blimpl :A conserved transcriptional repressor critical for differentiation of many tissues [ J ]. Exp Cell Res ,2009,315 (7) : 1077-1084.
  • 6Hayashi K, De Sousa Lopes SM, Surani MA. Germ cell specification in mice [ J ]. Science,2007,316 ( 5823 ) :394-396.
  • 7Liew HP, Choksi SP, Wong KN, et al. Specification of vertebrate slow-twitch muscle fiber fate by the transcriptional regulator Blimpl [J]. Dev Biol,2008,324(2) :226-35.
  • 8Kurimoto K,Yamaji M ,Seki Y,et al. Specification of the germ cell lineage in mice:a process orchestrated by the PR-domain proteins, Blimpl and Prdml4 [ J ]. Cell Cycle ,2008,7 ( 22 ) :3514-3518.
  • 9Takaiaashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors [J]. Ce11,2006,126(4) :663-676.
  • 10Baxendale S, Davison C, Muxworthy C, et al. The B-cell maturation factor Blimpl specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling[ J]. Nat Genet,2004,36( 1 ): 88-93.

二级参考文献8

  • 1Calame KL, Lin KI, Tunyaplin C. Regulatory alechanisms that determine the development and function of plasma cells. Annu Rev Immunol, 2003, 21:205-230.
  • 2Saitou M, Payer B, O'Carroll D, et al. Blimpl and the emergence of the germ line during development in the mouse. Cell Cycle, 2005, 4 : 1736-1740.
  • 3Tam W, Gomez M, Chadburn A, et al. Mulational analysis of PRDMI indicates a tumor suppressor role in diffuse large B-cell lymphomas. Blood, 2006, 107:4090-4100.
  • 4Pasqualucci L, Compagno M, Houldsworth J, el al. lnactivalion of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma. JEM, 2006, 203:311-317.
  • 5Garcia JF, Roncador G, Garcia JF, et al. PRDM1/BLIMP-1 expression in multiple B and T-cell lymphonla. Haematologica, 2006, 91:467-4-74.
  • 6岳文涛 赖百塘 汪蕙 等.155例肺癌中p53基因突变的研究[J].中华肿瘤杂志,1999,21:141-141.
  • 7郑书芳,柯杨.人类胃粘膜上皮永生细胞株中APC、Rb、c-met基因拷贝数研究[J].中华肿瘤杂志,1999,21(6):409-411. 被引量：2
  • 8赖春宁,江泽飞,宋三泰,王建安,黎燕,沈倍奋.186例乳腺癌患者BRCA1基因突变检测[J].中华肿瘤杂志,2001,23(6):483-485. 被引量：20

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医学综述
2010年 第1期

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