补气活血方治疗多发性梗死性痴呆的临床研究

The Clinical Study of "Buqihuoxue Prescription" in Treatment of Multiple Infarct Dementia

目的:观察补气活血方治疗多发性梗死性痴呆的临床疗效及安全性。方法:将30例多发性梗死性痴呆患者随机分为治疗组和对照组,治疗组采用补气活血方治疗,对照组采用脑复康治疗。分别于治疗前、后8周采用简易智能量表(MMSE)、修订的长谷川智力量表(HDS)、韦氏记忆量表(WMS)和日常生活自理能力量表(ADL)评定智能,观察治疗前后安全性、中医证候及脑血流动力学变化情况。结果:治疗8周后,两组患者各项评分均优于治疗前(P<0.05,P<0.01),中医证候及脑血管平均血流速度较治疗前有明显改善,且治疗组优于对照组(P<0.05,P<0.01)。结论:补气活血方,治疗多发性梗死性痴呆安全有效、疗效显著。

Objective：To observe the effect of＂Buqihuoxue prescription＂in treatment of multiple infarct dementia.Methods：60 cases were randomly divided into two groups：therapeutic group and control group.Patients in the therapeutic group were treated by＂Buqihuoxue prescription＂.The efficacies were assessed with MMSE、HDS 、WMS and ADL.The safety and the average cerebral blood flow was also assessed.Results：After 8 weeks treatment with＂Buqihuoxue prescription＂,the scores of MMSE、HDS、WMS、ADL and the parameters of the average cerebral blood flow in treatment group were significantly better than that of the control group（P0.05,P0.01）.No significant adverse events were found in the two groups.Conclusion：It is effective and safe for＂Buqihuoxue prescription＂to treat the patient with multiple infarct dementia.