二苯乙烯苷对脂肪肝家鸭模型肝脂的干预效果及机制研究

Mechanism and Interventional Effect of Stilbene Glycoside on Liver Lipid in Model Ducks with Fatty Liver

目的:考查二苯乙烯苷对脂肪肝家鸭模型肝脂的干预效果,探讨其作用机制。方法:复制脂肪肝家鸭模型,以二苯乙烯苷进行干预,考查家鸭体重、肝指数、肝脂、脂蛋白脂肪酶(LPL)、肝脂酶(HL)、肝脏病理变化,并进行统计分析。结果:二苯乙烯苷具有降低脂肪肝家鸭模型体重、肝指数、肝脏TG、TC,升高肝脏LPL、HL活性,改善肝脏病理形态的作用。不同剂量二苯乙烯苷干预脂肪肝效果有所差异,在剂量为13～52mg范围内随剂量递增,效果渐佳。结论:二苯乙烯苷具有抗脂肪肝作用,且呈剂量依赖性,其机制可能与提高肝脏LPL、HL活性,调节脂代谢,保护肝细胞有关。

Objective：To study the interventional effects and therapeutic mechanism of stilbene glycoside on liver lipid in a duck models with fatty liver.Methods：Established the duck models of fatty liver.After treated with stilbene glycoside,the index of body weight,ratio of liver weight/body weight,liver lipid,lipoprotein lipase（LPL）,hepatic lipase（HL）,liver pathology,liver functional influence was observed and compared between each group.Results：Stilbene glycoside team can decreased the body weight,ratio of liver weight/body weight,liver TG and TC,improved the LPL and HL activities,and meliorated liver pathological changes of model ducks.Stilbene glycoside team of different doses had different interventional effects in the experiment.The increase of doses accompanied by gradually adding effect in the 13~52mg doses.Conclusion：Stilbene glycoside can improve the fatty liver excellently in a dose-dependent manner.Therapeutic mechanism of its may be related to improving the LPL and HL activities,adjusting the disorder of lipid metabolism,protecting liver cell.