维A酸、三氧化二砷、柔红霉素联合诱导治疗急性早幼粒细胞白血病疗效观察

The effect of using victoria A acid,arsenic trioxide,daunorubicin to cure of acute promyelocytic leukemia

目的研究维A酸、三氧化二砷、柔红霉素诱导治疗急性早幼粒细胞白血病的效果。方法选择初治急性早幼粒细胞白血病患者30例,将其随机分为对照组和观察组,各15例。对照组采用维A酸单药诱导化疗,观察组采用维A酸、三氧化二砷、柔红霉素三药诱导化疗,观察2组的临床疗效。结果观察组达到完全缓解的时间明显缩短,相同治疗时间后外周血中早幼粒细胞明显降低,无维A酸综合征发生,患者耐受性好。结论维A酸、三氧化二砷、柔红霉素三药诱导化疗可作为急性早幼粒细胞白血病高危患者的首选治疗方案。

Objective To study effect of using victoria A acid,arsenic trioxide,daunorubicin to cure of acute promyelocytic leukemia. Methods 30 cases petients with acute promyelocytic leukemia were randomly divided into control group and observation group, all 15 patients. Control group were gave asingle-agent induction chemotherapy with victoria A acid,while observation group with victoria A acid, arsenic trioxide, daunorubiein induction chemotherapy. Compared clinical effect between two groups. Results Time of complete remission and the percentage of promyelocyte in peripheral blood were significantly im- provement in observation group,no-victoria A acid syndrome happened,and tolerance of patients was good. Conclusion In- duction chemotherapy of using victoria A acid,arsenic trioxide,daunorubicin for acute promyelocytic leukemia patients should be the first choice management modality.