摘要
用健康家兔经口服给药(剂量为30mg/kg),研究甲砜霉素及HP-β-CD甲砜霉素的药动学规律。以RP-HPLC法测定血浆中甲砜霉素的浓度,药物浓度-时间数据用3P97药动学程序软件处理。家兔单剂量口服给药甲砜霉素和HP-β-CD甲砜霉素血药浓度-时间数据均符合一级吸收一室开放模型。甲砜霉素主要动力学参数为:Lagtime(0.05±0.02)h,t1/2ka(0.83±0.02)h,t1/2ke(2.27±0.31)h,T(peak)(1.84±0.12)h,C(max)(6.98±0.95)mg/L,AUC(34.98±0.68)mg(/L·h),F(110.74±0.02)%。HP-β-CD甲砜霉素主要动力学参数为:Lagtime(0.02±0.01)h,t1/2ka(0.91±0.16)h,t1/2ke(0.86±0.15)h,T(peak)(0.96±0.07)h,C(max)(8.59±0.55)mg/L,AUC(43.02±0.87)mg(/L·h),F(142.07±0.02)%。HP-β-CD甲砜霉素在家兔体内的药动学特征表现为分布广泛,消除迅速;口服给药吸收迅速且完全,生物利用度高。
The pharmacokinetic regulations of thiamphenicol and HP-β-CD thiamphenicol were investigated by taken oral administration at a dosage of 30 mg/kg to healthy rabbits. The concentration of thiamphenicol in plasma was determined by RP-HPLC, and the data of concentration-time were analyzed by pharmacokinetic-eompartment analysis soft （3P97）. The data of eoncentration-time after oral administration of thiamphenieol and HP-β-CD thiamphenicol were all fitted to a one-compartment open model with first-order absorption. The main pharmacokinetie parameters of thiamphenieol were as follows： Lagtime （0. 05 ±0. 02） h, t1/2ka （0. 83 ±0. 02） h, t1/2ke （2.27 ±0. 31 ） h, T （peak） （1. 84 ±0. 12） h, C （max） （6. 98 ±0. 95） mg/L, AUC （34. 98 ±0. 68） mg/ （L·h） and F （110. 74 ±0. 02） %. The main pharmacokinetic parameters of HP-β-CD thiamphenicol were as follows： Lagtime （0. 02 ±0. 01） h, t1/2ka （0. 91 ±0. 16） h, t1/2ke （0.86 ±0. 15） h, T（peak） （0.96 ±0. 07） h, C （max） （8.59 ±0. 55） mg/L, AUC （43.02 ±0. 87） mg/（L ·h）, F （142.07 ±0. 02） %. The pharmaeokinetic characteristics of HP-β-CD thiamphenicol in healthy rabbits manifested the rapid and complete absorption, wide distribution, rapid elimination and the high bioavailability by the oral routes.
出处
《湖南农业科学》
2009年第12期11-14,共4页
Hunan Agricultural Sciences
基金
江苏畜牧兽医职业技术学院基金项目(200717)
