粒细胞巨噬细胞集落刺激因子在人类鼻息肉及鼻息肉病组织中的表达

Study on the expression of GM-CSF in human nasal polyp and polyposis

目的探讨粒细胞巨噬细胞集落刺激因子(GM-CSF)在人类鼻息肉及鼻息肉病中表达水平的差异。方法分别采用双抗体夹心酶联免疫吸附测定法及免疫组织化学SP法检测30例鼻息肉标本(鼻息肉组)、23例鼻息肉病标本(鼻息肉病组)及15例下鼻甲部分切除术患者下鼻甲粘膜标本(对照组)中GM-CSF的表达状况。结果鼻息肉病中GM-CSF含量明显高于鼻息肉组,鼻息肉组又明显高于对照组,且每两组间差异有统计学意义(P<0.01)。结论鼻息肉病的高复发可能和GM-CSF的高表达水平有关,可以作为区分鼻息肉病和鼻息肉的重要参考指标之一。

Objective To study the differences of GM-CSF in human nasal polyp and nasal polyposis.Meth-ods Using ELISA technique and SP immunohistochemical method detect the expressions of GM-CSF in 30 cases of nasal polyp、23 cases of nasal polyposis and 15 cases of inferior nasal concha.Results The statistical analysis showed that the level of GM-CSF had significant difference between either two groups（P0.01）.Conclusion The high expression of GM-CSF in nasal polyposis may contribute to the recurrence of nasal polyposis at a high level,while it can be regarded as an important diagnostic indicator for discriminating nasal polyps and nasal polyposis.