摘要
目的：研究肉苁蓉总甙（ＧＣＳ）对小鼠组织的抗氧化作用。方法：采用邻苯三酚自氧化、硫代巴比妥酸（ＴＢＡ）和荧光法，分别测定小鼠心、肝、脑、肾组织中ＳＯＤ活性、ＭＤＡ及脂褐质含量。结果：ＧＣＳ（１２５ｍｇ／ｋｇ，２５０ｍｇ／ｋｇ）组能显著提高脑、肾组织中ＳＯＤ活性，２５０ｍｇ／ｋｇ时提高心、肝组织中ＳＯＤ活性，并显著降低各组织ＭＤＡ及脂褐质含量。结论：结果提示ＧＣＳ能有效地提高机体组织抗氧化能力，防止组织脂质过氧化损伤。
Objective:To study the anti-oxidative action of GCS in the tissues of mice.Method:Contents of superoxide dismutase (SOD),malondialdehyde (MDA)and lipofuscin in the heart,liver,brain and kidney of mice were measured,using pyrogallic acid,thiobarbi turic acid(TBA)and fluorescent technique respectively.Result :It was found that the GCS (125mg/kg,250mg/kg)had a significantly higher SOD activity and lower MDA contents in brain and kidney than that in control group.GCS(250mg/kg)enhanced SOD activity in the heart and liver, declined contents of MDA and lipofuscin in all tissues.Conclusion:The results suggest that GCS could increase the antioxidative action in vivo significantly and prevent lipoperoxidative damages in tissues.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1998年第9期554-555,共2页
China Journal of Chinese Materia Medica
基金
国家中医药管理局科研基金
关键词
肉苁蓉
总甙
超氧化物歧化酶
丙二醛
抗氧化
glycosides of Cistanche
superoxides dismutase
malondialdehyde
lipofuscin
antioxidation
