计划免疫管理前后出生儿童3～5岁时血清乙型肝炎病毒感染率调查

The Serological Survey of HBV Infection Rate in 3-5 year old Children Born Before and After the Implementation of EPI

通过对乙型肝炎（乙肝）疫苗计划免疫（计免）管理前后３年出生的儿童３～５岁时血清中乙肝病毒感染指标比较看出，随着新生儿乙肝疫苗接种率的提高，３～５岁儿童的ＨＢｓＡｇ阳性率、乙肝自然感染率由计免管理前的１．１６％、１４．５９％下降至计免管理后的０．２９％、０．８８％；抗－ＨＢｓ阳性率由６００３％上升到８３．５８％。证明了对所有新生儿纳入计免管理，进行乙肝疫苗接种。

In order to investigate the changes of HBV infection rate after the implementation of EPI (1990) in children,we selected,in 1992,603 children of 3-5 years old born 3 years before (1987-1989) and again,in 1995,682 children of 3-5 years old born after (1990-1992) the EPI in the same kindergarten in Huangshi city to detect their serum HBsAg and anti-HBs.The results showed that following the increasement of immunization coverage rate of the newborns,the HBsAg positive rate and HB natural infection rate decreased from 1 16% and 14 59% before EPI to 0 29% and 0 88% after EPI respectively,anti-HBs positive rate raised from 60 03% to 83 58%.The data proved that taking all the newborns into EPI is the most effective way to control and eliminate hepatitis B.