COPD稳定期患者血栓前状态与全身炎症反应关系的研究

Study on Correlation between Systemic Inflammatorome and Prethrombotic State in Patients with Stable COPD

目的:通过检测CRP及VCAM-1、D-二聚体在稳定期COPD患者中的水平,探讨血栓前状态与全身炎症反应关系。方法:选取COPD稳定期患者46例和健康对照组28例,测量两组的肺功能和血浆中CRP、sVCAM-1、D-二聚体的水平。结果:COPD组CRP水平显著高于对照组水平;COPD组血液sVCAM、D-D水平显著高于对照组;COPD组患者血液CRP、sVCAM-1、D-D水平与FEV1.0%预计值呈负相关;COPD组血液CRP与sVCAM-1、D-D呈正相关。结论:COPD稳定期患者存在全身炎症反应和血栓前状态。COPD患者的全身炎症反应有助于形成PTS。

Objective：To observe the levels of serum of CRP and D-D,sVCAM-1 in patients with stable COPD and to study the relationship between systemic inflammatorome and PTS. Methods ：48 patients with stable COPD and 26 healthy persons（control group） were measured lung function and the levels of CRP,D-D,sVCAM-1 in blood plasma by ELISA. Results：The level of CRP in COPD group was significantly higher than those of control group. The level of D-D in COPD group was significantly higher than those of control group. The level of sVCAM in COPD group was significantly higher than those of control group. There was significant negative correlation between CRP and FEV1 % in COPD group. In COPD group,there was significant positive correlation between CRP and D-D;There was significant positive correlation between CRP and sVCAM-1. Conclusion：Systemic inflammatorome and PTS exist in patients with stable COPD. Systemic inflammatorome contribute to the formation of PTS in stable COPD.