胃癌组织中Galectin-3和Survivin蛋白表达与其临床病理学特征的关系

The relationship between expression of Galectin-3,Survivin and clinicopathological features in gastric carcinoma tissuess

目的探讨Galectin-3蛋白和凋亡抑制蛋白Survivin的表达与胃癌组织临床病理特征之间的关系。方法采用免疫组织化学SP法对52例手术切除胃癌组织及15例癌旁正常胃粘膜组织中Galectin-3和Survivin的表达进行了检测。结果胃癌组织中Galectin-3、Survivin的表达均增强且呈正相关(r=1.203),其阳性率分别为76.9%、73.1%,与正常胃粘膜26.7%、0%有显著差异(P<0.05),二者在胃癌中的表达与淋巴结转移呈正相关(P<0.05),TNM高分期较低分期组织中的表达均显著增高(P<0.05),低分化胃癌Survivin表达率明显高于高中分化者(P<0.05);Galectin-3、Survivin表达与胃癌病理组织学分型均无相关性(P>0.05);Galectin-3在胃癌高中、低分化癌两组间无统计学意义(P>0.05)。结论Galectin-3和Survivin的表达与胃癌的演变过程密切相关,联合检测二者有助于胃癌的早期诊断及预后的评估,为肿瘤的临床治疗提供新的思路。

Objective To study the relationship between the expression of Galectin-3,Survivin and clinicopathological features in gastric carcinoma tissues. Methods By immunohistochemical SP method in 52 gastric carcinoma tissues and 15 normal examples about Galectin-3 and Survivin of their expression. Results The positive rate of Galectin-3 and Survivin were 76.9%,73.1% in gastric cancer tissues and positive relationship（r=1.203） and significantly higher（P〈0.05）;expression in high stage was higher than low stage（P〈0.05）;expression of Survivin in low differentiated was higher than high differentiated（P〈0.05）;expression of Galectin-3、Survivin had no correlation with histological type in gastric cancer（P〉0.05）;Galectin-3 had no meaning in gastric cancer about statics about high differentiated and differentiated（P〉0.05）. Conclusions The expression of Galectin-3,Survivin are closely related to the evolution of gastric cancer,through test that they are good for assessment about diagnosis and prognosis ingastric cancer,give new way about treatment in cancer.