摘要
目的探讨急性心肌梗死(AMI)患者梗死相关血管与氮末端脑钠素前体(NT-proB-NP)的相关性。方法入选诊断明确的因AMI行急诊经皮冠状动脉介入治疗术患者共计112例,其中男性91例,女性21例。根据选择性冠状动脉造影影像学特征结合心电图诊断的AMI部位来确定梗死相关血管。所有患者入院后均行血浆NT-proBNP检测及经胸超声心动图等检查,分析其与梗死相关血管的相关性。结果梗死相关血管为前降支的患者NT-proBNP水平要明显高于梗死相关血管为回旋支或右冠状动脉患者,其差异有显著统计学意义(2069.071817.68versus969.91569.83or1164.811075.79pg/ml,P=0.004)。结论血浆NT-proBNP水平与AMI患者的梗死相关血管有关,NT-proBNP能反映心肌急性缺血损伤的程度及病情轻重。
Objective To investigate the relationship between N-terminal pro-brain natriuretie peptide （NT-proBNP） and the infarction-related artery in patients with acute myocardial infarction. Methods We studied 112 patients （91 men,21 women） with acute myocardial infarction whose plasma NT-proBNP level was measured at hospital admission. All recruited patients underwent primary percutaneous coronary intervention,electrocardiogram and echocardiographic examination. The infarction-related artery was confirmed by coronary angiography and electrocardiogram. Results Left descending coronary artery as infarction-relat- ed artery was associated with higher NT-proBNP than left circumflex artery or right coronary artery as infarction-related artery （2069.07 ±1817.68 versus 969.91 ± 569. 83 or 1164. 81 ±1075.79 pg/ml, P = 0.004）. Conclusion NT-proBNP appears to be associated with infarction-related artery in patients with AMI. Ischemia may be a stimulus for NT-proBNP release, reflecting the severity of ischemic insult.
出处
《中国分子心脏病学杂志》
CAS
2009年第6期366-369,共4页
Molecular Cardiology of China
基金
广东省医学科研基金(A2009049)
关键词
氮末端脑钠素前体
梗死相关血管
急性心肌梗死
急诊经皮冠状动脉介入治疗术
N-terminal pro-brain natriuretie peptide
Infarction-related artery
Acute myocardial infarction
Primary percutaneous coronary intervention
