P-选择素与缺血性脑血管病

P-selectin and ischemic cerebrovascular disease

P．选择素又称CD62，通过介导内皮细胞和血小板的活化以及动脉粥样硬化的形成和发展等过程，促进缺血性脑血管病的发生。多项研究证实，P-选择素在缺血性脑血管病危险因素，如高血压、糖尿病、高胆固醇血症、心脏病、吸烟、酗酒、高纤维蛋白原血症等的发生和发展中起重要作用。P-选择素能否作为独立危险因素预测缺血性脑血管病的发生，尚待进一步研究证实。

P-selectin is also known as CD62. It promotes the occurrence of ischemic cerebrovascular disease by mediating the activation of endothelial cells and platelets as well as the processes of the formation and development of atherogenesis. A number of studies have confirmed that P-selectin plays important roles in the occurrence and development of the risk factors （such as hypertension, diabetes, hypercholesterolemia, heart disease, smoking, alcohol abuse and hyperfibrinogenemia） for ischemic cerebrovascular disease. It remains to be confirmed by further studies whether P-selectin can be used as an independent risk factor for predicting the occurrence of ischemic cerebrovascular disease.