热休克蛋白90在糖皮质激素受体信号通路中的分子伴侣作用

Mechanism of Heat Shock Protein 90 as Molecular Chaperone in Glucocorticoid Receptor Signal Pathway

在应激反应时,下丘脑-垂体-肾上腺轴(HPA)在机体的调节方面起主要作用,而糖皮质激素(GC)是HPA轴中的关键物质,因此在考量急性和慢性应激反应时,GC及其受体(GR)的变化常常是首选的研究内容。而GR正常构象的形成、激活、功能发挥与其分子伴侣-热休克蛋白90(HSP90)关系密切。综述了HSP90的结构和功能、GC-GR信号通路中GC和GR的作用机制以及HSP90在GR信号通路中的分子伴侣作用。

In the stress response, the hypothalamus-pituitary-adrenal axis （HPA） plays a major role in the regulation of body, while the glucoeorticoid （GC） is the key material in HPA-axis. Therefore, when acute and chronic stress reactions are evaluated, GC and its receptor （GR） are often the first choice. Moreover, the formation of the normal conformation, activation and function of GR is closely related to heat shock protein 90 （HSP90）. This article overviewed the structure and function of HSP90, the mechanism of GC and GR in GC-GR signal pathway, and the effect of HSP90 as molecular chaperone in glucoeorticoid receptor signal pathway.